Seong Jin Lee Selected Research

Proteins (Proteins, Gene)

11/2020	Heat Shock Protein 90 Inhibitors AUY922, BIIB021 and SNX5422 Induce Bim-mediated Death of Thyroid Carcinoma Cells.
1/2019	Evodiamine in combination with histone deacetylase inhibitors has synergistic cytotoxicity in thyroid carcinoma cells.
6/2018	Enigma Plays Roles in Survival of Thyroid Carcinoma Cells through PI3K/AKT Signaling and Survivin.
2/2017	Doxorubicin has a synergistic cytotoxicity with cucurbitacin B in anaplastic thyroid carcinoma cells.
10/2016	Synergistic cytotoxicity of BIIB021 with triptolide through suppression of PI3K/Akt/mTOR and NF-κB signal pathways in thyroid carcinoma cells.
2/2015	Novel heat shock protein 90 inhibitor NVP-AUY922 synergizes with the histone deacetylase inhibitor PXD101 in induction of death of anaplastic thyroid carcinoma cells.
11/2014	The hsp70 inhibitor VER155008 induces paraptosis requiring de novo protein synthesis in anaplastic thyroid carcinoma cells.
11/2011	Sphingosylphosphorylcholine attenuated β-amyloid production by reducing BACE1 expression and catalysis in PC12 cells.
5/2009	Effects of alpha-lipoic acid on transforming growth factor beta1-p38 mitogen-activated protein kinase-fibronectin pathway in diabetic nephropathy.

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Seong Jin Lee Research Topics

Disease

12	Anaplastic Thyroid Carcinoma 05/2017 - 04/2013
9	Type 2 Diabetes Mellitus (MODY) 10/2023 - 01/2006
8	Thyroid Neoplasms (Thyroid Cancer) 11/2020 - 01/2016
4	Hypertension (High Blood Pressure) 08/2023 - 01/2006
3	Infections 06/2018 - 09/2004
3	Graves Disease (Basedow Disease) 06/2018 - 01/2006
2	Dyslipidemias (Dyslipidemia) 08/2023 - 01/2023
2	Insulin Resistance 01/2023 - 03/2017
2	Obesity 01/2023 - 01/2020
2	Cardiovascular Diseases (Cardiovascular Disease) 11/2022 - 07/2009
2	Inflammation (Inflammations) 01/2022 - 12/2010
2	Neoplasms (Cancer) 11/2020 - 04/2013
2	Thyroid Diseases (Thyroid Disease) 01/2017 - 08/2005
2	Hyperthyroidism 07/2009 - 01/2006
1	Gallstones (Gallstone) 08/2023
1	Metabolic Syndrome (Dysmetabolic Syndrome X) 08/2023
1	Chronic Kidney Failure (Chronic Renal Failure) 01/2023
1	Hypotension (Low Blood Pressure) 01/2022
1	Atopic Dermatitis (Atopic Eczema) 01/2022
1	Skin Diseases (Skin Disease) 01/2022
1	Hepatocellular Carcinoma (Hepatoma) 01/2021
1	Carotid Artery Diseases 01/2020
1	Hypogonadism (Hypergonadotropic Hypogonadism) 01/2018
1	B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia) 02/2017
1	Lymphoma (Lymphomas) 02/2017
1	Graves Ophthalmopathy 01/2017
1	Prediabetic State (Prediabetes) 04/2016
1	Diabetes Mellitus 03/2016
1	B-Cell Lymphoma (Lymphoma, B Cell) 03/2016

Drug/Important Bio-Agent (IBA)

9	Proteins (Proteins, Gene)FDA Link 11/2020 - 05/2009
8	Heat-Shock Proteins (Heat-Shock Protein)IBA 11/2020 - 09/2014
6	Glucose (Dextrose)FDA LinkGeneric 01/2023 - 03/2011
5	CholesterolIBA 10/2023 - 01/2006
4	SurvivinIBA 06/2018 - 02/2015
3	Triglycerides (Triacylglycerol)IBA 08/2023 - 07/2009
3	Insulin (Novolin)FDA Link 01/2023 - 12/2006
3	5- (2,4- dihydroxy- 5- isopropylphenyl)- 4- (4- morpholin- 4- ylmethylphenyl)isoxazole- 3- carboxylic acid ethylamideIBA 11/2020 - 02/2015
3	Histone Deacetylase InhibitorsIBA 01/2019 - 02/2015
3	EnzymesIBA 06/2018 - 09/2004
2	HDL CholesterolIBA 08/2023 - 03/2017
2	Blood Glucose (Blood Sugar)IBA 08/2023 - 08/2010
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2022 - 12/2015
2	6- chloro- 9- (4- methoxy- 3,5- dimethylpyridin- 2- ylmethyl)- 9H- purin- 2- ylamineIBA 11/2020 - 10/2016
2	Histone Deacetylases (Histone Deacetylase)IBA 01/2019 - 02/2016
2	evodiamineIBA 01/2019 - 11/2018
2	Phosphotransferases (Kinase)IBA 06/2018 - 01/2011
2	LC15-0444IBA 01/2018 - 10/2017
2	Dipeptidyl-Peptidase IV InhibitorsIBA 01/2018 - 10/2017
2	Proto-Oncogene Proteins c-bcl-2 (Proto Oncogene Proteins c bcl 2)IBA 10/2017 - 05/2017
2	Mitogen-Activated Protein Kinase 3IBA 10/2017 - 02/2017
2	Mitogen-Activated Protein KinasesIBA 05/2017 - 05/2009
2	Reactive Oxygen Species (Oxygen Radicals)IBA 05/2017 - 02/2017
2	Paclitaxel (Taxol)FDA LinkGeneric 05/2017 - 04/2015
2	belinostatIBA 02/2016 - 02/2015
2	ApigeninIBA 12/2015 - 04/2013
2	herbimycinIBA 10/2015 - 12/2014
2	tanespimycin (17AAG)IBA 10/2015 - 04/2015
2	Peptides (Polypeptides)IBA 11/2011 - 09/2004
2	Thyroid HormonesIBA 05/2009 - 08/2005
2	Thioctic Acid (Lipoic Acid)IBA 05/2009 - 01/2009
2	AntioxidantsIBA 05/2009 - 01/2009
2	Superoxide DismutaseIBA 12/2006 - 01/2006
1	ORALIT (ORS)IBA 08/2023
1	CytokinesIBA 01/2022
1	Interferon-gamma (Interferon, gamma)IBA 01/2022
1	lipoprotein cholesterolIBA 01/2022
1	Dinitrochlorobenzene (DNCB)IBA 01/2022
1	ScopoletinIBA 01/2022
1	AlbuminsIBA 01/2021
1	Hemoglobins (Hemoglobin)IBA 01/2020
1	Methimazole (Thiamazole)FDA LinkGeneric 06/2018
1	Matrix Metalloproteinase 9 (Gelatinase B)IBA 01/2018
1	Metformin (Glucophage)FDA LinkGeneric 01/2018
1	Matrix Metalloproteinase 2 (Gelatinase A)IBA 01/2018
1	Luteinizing Hormone (Lutropin)FDA LinkGeneric 01/2018
1	Vascular Cell Adhesion Molecule-1 (Vascular Cell Adhesion Molecule 1)IBA 01/2018
1	Adenosine Monophosphate (AMP)IBA 10/2017
1	Protein Kinases (Protein Kinase)IBA 10/2017
1	Death Domain ReceptorsIBA 05/2017
1	celastrolIBA 05/2017
1	C-Reactive ProteinIBA 03/2017
1	STAT3 Transcription Factor (Signal Transducer and Activator of Transcription 3)IBA 02/2017
1	Doxorubicin (Adriamycin)FDA LinkGeneric 02/2017
1	cucurbitacin BIBA 02/2017
1	Janus Kinase 2IBA 02/2017
1	Immunoglobulins (Immunoglobulin)IBA 01/2017
1	Immunoglobulin G (IgG)IBA 01/2017
1	triptolideIBA 10/2016
1	Histone Acetyltransferases (Histone Acetyltransferase)IBA 10/2016
1	Glycated Hemoglobin (Glycosylated Hemoglobin)IBA 04/2016
1	Caspase 3 (Caspase-3)IBA 03/2016
1	theasinensin AIBA 02/2016
1	trichostatin A (A 300)IBA 02/2016
1	Vorinostat FDA Link 02/2016
1	Thyroxine (Levothyroxine)FDA LinkGeneric 01/2016
1	Thyrotropin (Thyroid-Stimulating Hormone)FDA Link 01/2016

Therapy/Procedure

3	Therapeutics 01/2016 - 08/2005
2	Cholecystectomy 08/2023 - 01/2023
1	Operative Surgical Procedures 08/2023
1	Conservative Treatment 06/2018